The N14 Letterkenny/ Lifford Rd is closed between Raphoe and Rossgier following a collision.
Gardaí and emergency services are at the scene of the crash, which occurred at around 12.50pm.
A garda spokesperson has confirmed that a car and an HGV were involved and asked witnesses or anyone with information to contact them at Letterkenny Garda Station on 074 916 7100.
Diversions are in place.
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